Herpes Simplex Virus 1/2 Antibody (IgM)

Clinical Significance:

HSV IgM is detectable in serum from >90% of patients with primary HSV infection. However, HSV IgM cannot be reliably used to diagnose acute/recent infection as it is also found in 30% of patients with reactivated HSV. This test may not distinguish between HSV-1 IgM and HSV-2 IgM due to cross-reactivity. To diagnose acute genital or mucosal HSV infection, direct detection from a lesion by culture or molecular methods is preferred. HSV IgM positivity should be confirmed by HSV-1/2 type-specific IgG testing.
If HSV 1 IgM screen is positive, HSV 1 IgM Titer will be performed at an additional charge (CPT code(s): 86695). 
If HSV 2 IgM Screen is positive, HSV 2 IgM Titer will be performed at an additional charge (CPT code(s): 86696).


Immunofluorescence Assay (IFA)
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

HSV 1 IgM ScreenNegative
HSV 2 IgM ScreenNegative

Alternative Name(s)

Herpes 1/2 IgM, Serum,Herpes Simplex Virus Serum